Koetschan et al. (2010) NAR 38:D275-9
Selig et al. (2008) NAR 36:D377-380.
Schultz et al. (2006) NAR 34:W704-7.
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ITS2 3D structure
(Keller et al. 2010)


Chlorophyta hypertree

(Buchheim et al. 2011)
Fig1, Fig2, Fig3, Fig4

Our selection of some ITS2 highlight papers

This is a subjective selection of some ITS2 highlight papers from the last 25 years concerning phylogenetics, ribogenesis, diagnostics and barcoding. In particular we singled out case studies from other groups in fungal, plant and animal research as well as review articles concerning the ITS2 secondary structure.
  • Chen S., Yao H., Han J., Liu C., Song J., Shi L., Zhu Y., Ma X., Gao T., Pang X., Luo K., Li Y., Li X., Jia X., Lin Y., Leon C. (2010):
    Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species.
    PLoS One 5(1):e8613
  • Moniz M.B.J., Kaczmarska I. (2009)
    Barcoding diatoms: Is there a good marker?
    Molecular Ecology Resources 9:65-74
  • Biffin E., Harrington M.G., Crisp M.D., Craven L.A., Gadek P.A. (2007)
    Structural partitioning, paired-sites models and evolution of the ITS transcript in Syzygium and Myrtaceae.
    Molecular Phylogenetics and Evolution 43:124-39
  • Alvarez I., Wendel J.F. (2003)
    Ribosomal ITS sequences and plant phylogenetic inference.
    Molecular Phylogenetics and Evolution 29:417-34
  • Goertzen L.R., Cannone J.J., Gutell R.R., Jansen R.K. (2003)
    ITS secondary structure derived from comparative analysis: implications for sequence alignment and phylogeny of the Asteraceae.
    Molecular Phylogenetics and Evolution 29:216-34
  • Coleman A.W. (2003)
    ITS2 is a double-edged tool for eukaryote evolutionary comparisons.
    Trends in Genetics 19:370-5
  • Coleman A.W., Vacquier V.D. (2002)
    Exploring the phylogenetic utility of ITS sequences for animals: a test case for abalone (Haliotis).
    Journal of Molecular Evolution 54:246-57
  • Côté C.A., Peculis B.A. (2001)
    Role of the ITS2-proximal stem and evidence for indirect recognition of processing sites in pre-rRNA processing in yeast.
    Nucleic Acids Research 29:2106-16
  • Coleman A.W. (2000):
    The significance of a coincidence between evolutionary landmarks found in mating affinity and a DNA sequence
    Protist 151(1):1-9
  • Turenne C.Y., Sanche S.E., Hoban D.J., Karlowsky J.A., Kabani A.M. (2000)
    Rapid identification of fungi by using the ITS2 genetic region and an automated fluorescent capillary electrophoresis system.
    Journal of Clinical Microbiology 37:1846-51
  • Joseph N., Krauskopf E., Vera M.I., Michot B. (1999)
    Ribosomal internal transcribed spacer 2 (ITS2) exhibits a common core of secondary structure in vertebrates and yeast.
    Nucleic Acids Research 27:4533-40
  • Hung G.C., Chilton N.B., Beveridge I., Gasser R.B. (1999)
    Secondary structure model for the ITS-2 precursor rRNA of strongyloid nematodes of equids: implications for phylogenetic inference.
    International Journal for Parasitology 29:1949-64
  • Mai J.C., Coleman A.W. (1997)
    The internal transcribed spacer 2 exhibits a common secondary structure in green algae and flowering plants.
    Journal of Molecular Evolution 44:258-71
  • Hershkovitz M.A., Zimmer E.A. (1996)
    Conservation patterns in angiosperm rDNA ITS2 sequences.
    Nucleic Acids Research 24:2857-67
  • Hershkovitz M.A., Lewis L.A. (1996)
    Deep-level diagnostic value of the rDNA-ITS region.
    Molecular Biology and Evolution 13:1276-95
  • Baldwin B.G. (1992)
    Phylogenetic utility of the internal transcribed spacers of nuclear ribosomal DNA in plants: an example from the compositae.
    Molecular Phylogenetics and Evolution 1:3-16
  • Michot B., Bachellerie J.P., Raynal F. (1983)
    Structure of mouse rRNA precursors. Complete sequence and potential folding of the spacer regions between 18S and 28S rRNA.
    Nucleic Acids Research 11(10):3375-91

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